https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Virtual histology of cortical thickness and shared neurobiology in 6 psychiatric disorders https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:43667 Wed 28 Sep 2022 13:52:58 AEST ]]> The relationship between white matter microstructure and general cognitive ability in patients with schizophrenia and healthy participants in the ENIGMA consortium https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:40457 Wed 27 Jul 2022 11:14:03 AEST ]]> Effect of immune activation during early gestation or late gestation on inhibitory markers in adult male rats https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45189 In situ hybridisation revealed that polyI:C offspring had: (1) SST mRNA reductions in the cingulate cortex and nucleus accumbens shell, regardless of MIA timing; (2) SSTR2 mRNA reductions in the cortex and striatum of GD19, but not GD10, MIA; (3) no alterations in cortical or striatal GAD1 mRNA of polyI:C offspring, but an expected reduction of PVALB mRNA in the infralimbic cortex, and; (4) no alterations in inhibitory markers in hippocampus. Maternal IL-6 response negatively correlated with adult offspring SST mRNA in cortex and striatum, but not hippocampus. These results show lasting inhibitory-related deficits in cortex and striatum in adult offspring from MIA. SST downregulation in specific cortical and striatal subregions, with additional deficits in somatostatin-related signalling through SSTR2, may contribute to some of the adult behavioural changes resulting from MIA and its timing.]]> Wed 26 Oct 2022 14:26:13 AEDT ]]> Analysis of shared heritability in common disorders of the brain https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:43392 Wed 22 Mar 2023 15:32:42 AEDT ]]> The genetic architecture of the human cerebral cortex https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:42676 Wed 22 Mar 2023 14:34:07 AEDT ]]> Cerebellar grey-matter deficits, cannabis use and first-episode schizophrenia in adolescents and young adults https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:19046 Wed 20 May 2020 07:09:22 AEST ]]> Virtual Ontogeny of Cortical Growth Preceding Mental Illness https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51029 Wed 16 Aug 2023 10:09:44 AEST ]]> Genetic markers of human evolution are enriched in schizophrenia https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:25928 −9) more prevalent in genomic regions that are likely to have undergone recent positive selection in humans (i.e., with a low NSS score). Variants in brain-related genes with a low NSS score confer significantly higher susceptibility than variants in other brain-related genes. The enrichment is strongest for schizophrenia, but we cannot rule out enrichment for other phenotypes. The false discovery rate conditional on the evolutionary proxy points to 27 candidate schizophrenia susceptibility loci, 12 of which are associated with schizophrenia and other psychiatric disorders or linked to brain development. Conclusions: Our results suggest that there is a polygenic overlap between schizophrenia and NSS score, a marker of human evolution, which is in line with the hypothesis that the persistence of schizophrenia is related to the evolutionary process of becoming human.]]> Wed 12 Aug 2020 09:42:59 AEST ]]> Genome-wide association study identifies five new schizophrenia loci https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14264 −11) was with rs1625579 within an intron of a putative primary transcript for MIR137 (microRNA 137), a known regulator of neuronal development. Four other schizophrenia loci achieving genome-wide significance contain predicted targets of MIR137, suggesting MIR137-mediated dysregulation as a previously unknown etiologic mechanism in schizophrenia. In a joint analysis with a bipolar disorder sample (16,374 affected individuals and 14,044 controls), three loci reached genome-wide significance: CACNA1C (rs4765905, P = 7.0 × 10−9), ANK3 (rs10994359, P = 2.5 × 10−8) and the ITIH3-ITIH4 region (rs2239547, P = 7.8 × 10−9).]]> Wed 11 Apr 2018 18:45:05 AEST ]]> Visual perception and processing in children with 22q11.2 deletion syndrome: associations with social cognition measures of face identity and emotion recognition https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30124 Wed 11 Apr 2018 17:22:19 AEST ]]> Duration mismatch negativity and P3a in first-episode psychosis and individuals at ultra-high risk of psychosis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:10485 Wed 11 Apr 2018 17:20:37 AEST ]]> Mismatch negativity (MMN) in freely-moving rats with several experimental controls https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:16819 Wed 11 Apr 2018 17:19:46 AEST ]]> Epidural auditory event-related potentials in the rat to frequency and duration deviants: evidence of mismatch negativity? https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:9724 Wed 11 Apr 2018 16:32:53 AEST ]]> Expression analysis in a rat psychosis model identifies novel candidate genes validated in a large case-control sample of schizophrenia https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:23292 Wed 11 Apr 2018 15:09:07 AEST ]]> No reliable association between runs of homozygosity and schizophrenia in a well-powered replication study https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:27630 Froh and schizophrenia (β = 4.86,CI(β) = [0.90,8.83],Z = 2.40,p = 0.02). Since Keller et al. (2012), several studies reported inconsistent association of ROH burden with complex traits, particularly in case-control data. These conflicting results might suggest that the effects of autozygosity are confounded by various factors, such as socioeconomic status, education, urbanicity, and religiosity, which may be associated with both real inbreeding and the outcome measures of interest.]]> Wed 11 Apr 2018 14:15:34 AEST ]]> Paracingulate sulcus morphology is associated with hallucinations in the human brain https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:22665 Wed 11 Apr 2018 12:37:33 AEST ]]> Mismatch negativity: translating the potential https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20577 Wed 11 Apr 2018 12:29:02 AEST ]]> Mismatch negativity in recent-onset and chronic schizophrenia: a current source density analysis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:16820 Wed 11 Apr 2018 12:28:20 AEST ]]> Nicotinic antagonist effects on functional attention networks https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:7853 Wed 11 Apr 2018 12:08:09 AEST ]]> Ten-year audit of clients presenting to a specialised service for young people experiencing or at increased risk for psychosis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:16754 Wed 11 Apr 2018 10:51:14 AEST ]]> Electrophysiological, cognitive and clinical profiles of at-risk mental state: the longitudinal Minds in Transition (MinT) study https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30417 Wed 11 Apr 2018 10:16:02 AEST ]]> Pre-pulse inhibition and antisaccade performance indicate impaired attention modulation of cognitive inhibition in 22q11.2 deletion syndrome (22q11DS) https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:16792 Wed 11 Apr 2018 09:36:57 AEST ]]> Muscarinic antagonist effects on executive control of attention https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:7855 Wed 11 Apr 2018 09:36:20 AEST ]]> 10Kin1day: a bottom-up neuroimaging initiative https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36591 Wed 10 Jun 2020 14:23:24 AEST ]]> Impact of rurality and substance use on young people at ultra-high risk for psychosis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36084 Wed 05 Feb 2020 14:23:07 AEDT ]]> Utility of risk-status for predicting psychosis and related outcomes: evaluation of a 10-year cohort of presenters to a specialised early psychosis community mental health service https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33211 without (35.4%, the reference group) and with psychiatric admissions (8.3%); and incomplete assessments (12.5%). High comorbidity levels were reported by the cohort (psychosocial problems, 61.1%; depression, 54.1%; substance misuse, 40.7%). UHR clients experienced similar psychosis transition rates to the reference group (17.3% vs. 14.6%; 8.9% vs. 9.1% within 2-years) and comparable rates of subsequent non-psychosis outcomes. A 25.9% conversion rate from early psychosis to schizophrenia was detected. However, among transitioning individuals, UHR clients faired relatively better, particularly with respect to changes in comorbidity and mental health contacts. Interventions tailored to current problems, recovery and psychological strengthening may be more appropriate than those based on estimated psychosis risk, which currently lacks clinical utility.]]> Wed 04 Sep 2019 10:05:29 AEST ]]> Genetic correlation between amyotrophic lateral sclerosis and schizophrenia https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:34119 -4) with schizophrenia polygenic risk scores explaining up to 0.12% of the variance in ALS (P=8.4 × 10-7). A modest increase in comorbidity of ALS and schizophrenia is expected given these findings (odds ratio 1.08-1.26) but this would require very large studies to observe epidemiologically. We identify five potential novel ALS-associated loci using conditional false discovery rate analysis. It is likely that shared neurobiological mechanisms between these two disorders will engender novel hypotheses in future preclinical and clinical studies.]]> Wed 04 Sep 2019 09:40:14 AEST ]]> Association of Structural Magnetic Resonance Imaging Measures with Psychosis Onset in Individuals at Clinical High Risk for Developing Psychosis: An ENIGMA Working Group Mega-analysis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49020 Wed 03 May 2023 12:31:22 AEST ]]> Subtypes in 22q11.2 deletion syndrome associated with behaviour and neurofacial morphology https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:23140 Tue 24 Aug 2021 14:35:16 AEST ]]> Estimation of Genetic Correlation via Linkage Disequilibrium Score Regression and Genomic Restricted Maximum Likelihood https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:44630 Tue 18 Oct 2022 12:11:18 AEDT ]]> Transcriptomic abnormalities in peripheral blood in bipolar disorder, and discrimination of the major psychoses https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:41878 Tue 16 Aug 2022 10:04:26 AEST ]]> The psychological and physiological sequel of child maltreatment: a forensic perspective https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:44239 Tue 11 Oct 2022 12:12:20 AEDT ]]> Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:34283 −15), which persisted after excluding loci implicated in previous studies (OR = 1.07, P = 1.7 × 10−6). CNV burden was enriched for genes associated with synaptic function (OR = 1.68, P = 2.8 × 10−11) and neurobehavioral phenotypes in mouse (OR = 1.18, P = 7.3 × 10−5). Genome-wide significant evidence was obtained for eight loci, including 1q21.1, 2p16.3 (NRXN1), 3q29, 7q11.2, 15q13.3, distal 16p11.2, proximal 16p11.2 and 22q11.2. Suggestive support was found for eight additional candidate susceptibility and protective loci, which consisted predominantly of CNVs mediated by nonallelic homologous recombination.]]> Tue 03 Sep 2019 18:30:49 AEST ]]> Cortical brain abnormalities in 4474 individuals with schizophrenia and 5098 control subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) consortium https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33388 Tue 03 Sep 2019 17:54:11 AEST ]]> A correction for sample overlap in genome-wide association studies in a polygenic pleiotropy-informed framework https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33389 Tue 03 Sep 2019 17:54:01 AEST ]]> Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50043 Thu 29 Jun 2023 14:38:49 AEST ]]> Functional MRI BOLD response to Tower of London performance of first-episode schizophrenia patients using cortical pattern matching https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:561 Thu 25 Jul 2013 09:10:39 AEST ]]> Dyssomnia in children diagnosed with attention deficit hyperactivity disorder: a critical review https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:12 Thu 25 Jul 2013 09:10:12 AEST ]]> Increased power by harmonizing structural MRI site differences with the ComBat batch adjustment method in ENIGMA https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:40024 Thu 21 Jul 2022 09:47:00 AEST ]]> E-technology social support programs for autistic children: can they work? https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38960 Thu 17 Mar 2022 13:04:30 AEDT ]]> Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:47202 Thu 15 Dec 2022 11:18:18 AEDT ]]> A polygenic resilience score moderates the genetic risk for schizophrenia: Replication in 18,090 cases and 28,114 controls from the Psychiatric Genomics Consortium https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54811 Thu 14 Mar 2024 14:24:56 AEDT ]]> Identification of gene loci that overlap between schizophrenia and educational attainment https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:34615 Thu 04 Apr 2019 09:04:20 AEDT ]]> Transcranial direct current stimulation https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:13749 Sat 24 Mar 2018 10:39:19 AEDT ]]> Consciousness and hallucinations in schizophrenia: secondary aspects of generalized neuropil pathology? (letter) https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:7292 Sat 24 Mar 2018 08:42:13 AEDT ]]> Visual scanning of faces in 22q11.2 deletion syndrome: attention to the mouth or the eyes? https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:9528 Sat 24 Mar 2018 08:35:32 AEDT ]]> Preliminary investigation of gene expression profiles in peripheral blood lymphocytes in schizophrenia https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:1288 Sat 24 Mar 2018 08:32:45 AEDT ]]> Functional MRI BOLD response to Tower of London performance of first-episode schizophrenia patients using cortical pattern matching https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:1772 Sat 24 Mar 2018 08:27:35 AEDT ]]> Visual scanpath abnormalities in 22q11.2 deletion syndrome: is this a face specific deficit? https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:12493 Sat 24 Mar 2018 08:17:11 AEDT ]]> Cerebellar grey matter deficits in first-episode schizophrenia mapped using cortical pattern matching https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:10763 Sat 24 Mar 2018 08:13:54 AEDT ]]> Australian schizophrenia research bank: a database of comprehensive clinical, endophenotypic and genetic data for aetiological studies of schizophrenia https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:10415 Sat 24 Mar 2018 08:12:38 AEDT ]]> Young rural people at risk for schizophrenia: time for mental health services to translate research evidence into best practice of care https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:10463 Sat 24 Mar 2018 08:09:11 AEDT ]]> Autonomic hyper-vigilance in post-infective fatigue syndrome https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:10148 Sat 24 Mar 2018 08:07:28 AEDT ]]> Mismatch negativity (MMN) reduction in schizophrenia - impaired prediction-error generation, estimation or salience? https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20443 Sat 24 Mar 2018 08:06:54 AEDT ]]> What's intact and what's not within the mismatch negativity system in schizophrenia https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:18307 Sat 24 Mar 2018 08:04:41 AEDT ]]> Repetition suppression of the rat auditory evoked potential at brief stimulus intervals https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:19902 Sat 24 Mar 2018 08:03:48 AEDT ]]> Divergent patterns of social cognition performance in autism and 22q11.2 deletion syndrome (22q11DS) https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20081 Sat 24 Mar 2018 08:00:08 AEDT ]]> Temporal processing ability is related to ear-asymmetry for detecting time cues in sound: a mismatch negativity (MMN) study https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:17969 Sat 24 Mar 2018 07:56:23 AEDT ]]> Age effects on cerebral grey matter and their associations with psychopathology, cognition and treatment response in previously untreated schizophrenia patients https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20972 Sat 24 Mar 2018 07:54:21 AEDT ]]> Biological insights from 108 schizophrenia-associated genetic loci https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:21465 DRD2 and several genes involved in glutamatergic neurotransmission highlight molecules of known and potential therapeutic relevance to schizophrenia, and are consistent with leading pathophysiological hypotheses. Independent of genes expressed in brain, associations were enriched among genes expressed in tissues that have important roles in immunity, providing support for the speculated link between the immune system and schizophrenia.]]> Sat 24 Mar 2018 07:52:31 AEDT ]]> Transcranial direct current stimulation of prefrontal cortex: an auditory event-related potential and proton magnetic resonance spectroscopy study https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20124 Sat 24 Mar 2018 07:51:45 AEDT ]]> Gene expression profiling in treatment-naive schizophrenia patients identifies abnormalities in biological pathways involving AKT1 that are corrected by antipsychotic medication https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20137 Sat 24 Mar 2018 07:51:34 AEDT ]]> Transcranial direct current stimulation of prefrontal cortex: an auditory event-related potential study in schizophrenia https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:18814 Sat 24 Mar 2018 07:51:01 AEDT ]]> Generalization of cognitive training in an Australian sample of schizophrenia patients https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:19993 Sat 24 Mar 2018 07:50:47 AEDT ]]> Variability in working memory performance explained by epistasis vs polygenic scores in the ZNF804A pathway https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:18570 Sat 24 Mar 2018 07:50:10 AEDT ]]> Deviant matters: duration, frequency, and intensity deviants reveal different patterns of mismatch negativity reduction in early and late schizophrenia https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:5114 Sat 24 Mar 2018 07:48:57 AEDT ]]> Dual constraints on synapse formation and regression in schizophrenia: more evidence required (letter) https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:5437 Sat 24 Mar 2018 07:48:14 AEDT ]]> Functional magnetic resonance brain imaging of executive cognitive performance in young first-episode schizophrenia patients and age-matched long-term cannabis users https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:26883 Sat 24 Mar 2018 07:41:40 AEDT ]]> A randomised controlled trial of cognitive behaviour therapy versus non-directive reflective listening for young people at ultra high risk of developing psychosis: the detection and evaluation of psychological therapy (DEPTh) trial https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:29913 Sat 24 Mar 2018 07:40:55 AEDT ]]> Primary and secondary neural networks of auditory prepulse inhibition: a functional magnetic resonance imaging study of sensorimotor gating of the human acoustic startle response https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:26102 Sat 24 Mar 2018 07:39:52 AEDT ]]> Psychophysiological correlates of developmental changes in healthy and autistic boys https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:27424 Sat 24 Mar 2018 07:34:59 AEDT ]]> Transcriptome-wide mega-analyses reveal joint dysregulation of immunologic genes and transcription regulators in brain and blood in schizophrenia https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:25812 postmortem brain tissue, and later in studies of peripheral blood. The collective body of schizophrenia microarray literature contains apparent inconsistencies between studies, with failures to replicate top hits, in part due to small sample sizes, cohort-specific effects, differences in array types, and other confounders. In an attempt to summarize existing studies of schizophrenia cases and non-related comparison subjects, we performed two mega-analyses of a combined set of microarray data from postmortem prefrontal cortices (n = 315) and from ex-vivo blood tissues (n = 578). We adjusted regression models per gene to remove non-significant covariates, providing best-estimates of transcripts dysregulated in schizophrenia. We also examined dysregulation of functionally related gene sets and gene co-expression modules, and assessed enrichment of cell types and genetic risk factors. The identities of the most significantly dysregulated genes were largely distinct for each tissue, but the findings indicated common emergent biological functions (e.g. immunity) and regulatory factors (e.g., predicted targets of transcription factors and miRNA species across tissues). Our network-based analyses converged upon similar patterns of heightened innate immune gene expression in both brain and blood in schizophrenia. We also constructed generalizable machine-learning classifiers using the blood-based microarray data. Our study provides an informative atlas for future pathophysiologic and biomarker studies of schizophrenia.]]> Sat 24 Mar 2018 07:34:35 AEDT ]]> CX3CR1 is dysregulated in blood and brain from schizophrenia patients https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:27390 Sat 24 Mar 2018 07:34:09 AEDT ]]> White matter disruptions in schizophrenia are spatially widespread and topologically converge on brain network hubs https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30942 Sat 24 Mar 2018 07:33:42 AEDT ]]> Schizophrenia risk from complex variation of complement component 4 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30050 Sat 24 Mar 2018 07:31:15 AEDT ]]> LD score regression distinguishes confounding from polygenicity in genome-wide association studies https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:28311 Sat 24 Mar 2018 07:27:06 AEDT ]]> Is it time to move mismatch negativity into the clinic? https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:24009 Sat 24 Mar 2018 07:16:46 AEDT ]]> Contrasting genetic architectures of schizophrenia and other complex diseases using fast variance-components analysis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:23305 Sat 24 Mar 2018 07:16:19 AEDT ]]> Partitioning heritability by functional annotation using genome-wide association summary statistics https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:23306 Sat 24 Mar 2018 07:16:19 AEDT ]]> Finding the needle in the haystack: a review of microarray gene expression research into schizophrenia https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:22172 Sat 24 Mar 2018 07:14:59 AEDT ]]> Brain imaging correlates of emerging schizophrenia https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:23563 Sat 24 Mar 2018 07:14:10 AEDT ]]> Mismatch negativity (MMN) as biomarker predicting psychosis in clinically at-risk individuals https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:24085 Sat 24 Mar 2018 07:11:47 AEDT ]]> Electrophysiological mismatch response recorded in awake pigeons from the avian functional equivalent of the primary auditory cortex https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:23992 Sat 24 Mar 2018 07:10:23 AEDT ]]> Wnt receptor gene FZD1 was associated with schizophrenia in genome-wide SNP analysis of the Australian Schizophrenia Research Bank cohort https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:44131 Sat 08 Oct 2022 12:36:32 AEDT ]]> Gene expression imputation across multiple brain regions provides insights into schizophrenia risk https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:47780 Mon 30 Jan 2023 10:58:57 AEDT ]]> Effects of immune activation during early or late gestation on N-methyl-D-aspartate receptor measures in adult rat offspring https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:32572 Mon 23 Sep 2019 12:39:53 AEST ]]> Youth mental health competencies in regional general practice https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49539 Mon 22 May 2023 08:45:30 AEST ]]> The role of polygenic risk score gene-set analysis in the context of the omnigenic model of schizophrenia https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:42338 N = 29,125 cases and 34,836 controls), a robust polygenic signal was observed from gene sets based on TCF4, FMR1, upregulation from MIR137 and downregulation from CHD8. Additional analyses revealed a constant floor effect in the amount of variance explained, consistent with the omnigenic model. Thus, we report that putative core gene sets showed a significant effect above and beyond the floor effect that might be linked with the underlying omnigenic background. In addition, we demonstrate a method to quantify the contribution of specific gene sets within the omnigenic context.]]> Mon 22 Aug 2022 14:00:20 AEST ]]> Large-scale analysis of structural brain asymmetries in schizophrenia via the ENIGMA consortium https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50977 Mon 14 Aug 2023 15:24:38 AEST ]]> Schizophrenia risk conferred by rare protein-truncating variants is conserved across diverse human populations https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50972 Mon 14 Aug 2023 15:19:39 AEST ]]> Age at first birth in women is genetically associated with increased risk of schizophrenia https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:43035 Mon 12 Sep 2022 11:49:25 AEST ]]> A molecule-based genetic association approach implicates a range of voltage-gated calcium channels associated with schizophrenia https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:42814 Mon 05 Sep 2022 14:06:54 AEST ]]> Effects of immune activation during early or late gestation on schizophrenia-related behaviour in adult rat offspring https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33142 Mon 03 Sep 2018 12:55:09 AEST ]]> Intact sensorimotor gating in adult attention deficit hyperactivity disorder https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:6968 Mon 03 Feb 2020 10:35:05 AEDT ]]> Mapping genomic loci implicates genes and synaptic biology in schizophrenia https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49672 Fri 26 May 2023 15:35:47 AEST ]]> Population-based identity-by-descent mapping combined with exome sequencing to detect rare risk variants for schizophrenia https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:42186 n = 3,473) by performing identity-by-descent (IBD) mapping followed by exome sequencing of individuals identified as sharing risk haplotypes to search for rare risk variants in coding regions. We identified 45 rare haplotypes (>1 cM) that were significantly more common in cases than controls. By exome sequencing 105 haplotype carriers, we investigated these haplotypes for functional coding variants that could be tested for association in independent GWAS samples. We identified one rare missense variant in PCNT but did not find statistical support for an association with schizophrenia in a replication analysis. However, IBD mapping can prioritize both individual samples and genomic regions for follow-up analysis but genome rather than exome sequencing may be more effective at detecting risk variants on rare haplotypes.]]> Fri 26 Aug 2022 10:49:17 AEST ]]> A Comparison of Ten Polygenic Score Methods for Psychiatric Disorders Applied Across Multiple Cohorts https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:48644 Fri 24 Mar 2023 13:44:42 AEDT ]]> Neuroanatomical heterogeneity and homogeneity in individuals at clinical high risk for psychosis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51931 1.5 SD) in SA, 118 (7.47%) in CT and 161 (10.20%) in SV. Psychosis transition was not significantly associated with any measure of heterogeneity. Overall, our examination of neuroanatomical heterogeneity within the CHR-P state indicated greater divergence in neuroanatomical profiles at an individual level, irrespective of psychosis conversion. Further large-scale investigations are required of those who demonstrate marked deviation.]]> Fri 22 Sep 2023 11:07:30 AEST ]]> Brain ageing in schizophrenia: evidence from 26 international cohorts via the ENIGMA Schizophrenia consortium https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51559 Fri 08 Sep 2023 16:29:26 AEST ]]> BrainGENIE: The Brain Gene Expression and Network Imputation Engine https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51344 Fri 01 Sep 2023 13:34:14 AEST ]]>